It is my understanding that the problem lies in the lightening transient peaks that can draw up to 10x the normal current. Here are a few quotes:
Shunyata.
The key to choosing the ideal power-distributor system lies within the concept of keeping things simple and uncomplicated.... Designs that use transformers, coils and baluns are inductive and by their nature impede instantaneous current delivery. This may cause a loss of phase and time coherence (PraT), losses in perceived voice and instrument weight and overall compression of dynamics.
Placing anything in front of an electronics system that restricts, impedes or slows the DTCD of AC power will degrade the ultimate performance of the system. This is why most electronics manufacturers discourage the use of power conditioners that interfere with instantaneous current flow.
Furman Conditioners
One of the downsides to a computer style mains conditioners in a hifi context is that they current limit, so they may clean up the mains and yield a cleaner sound some of the time, when there is a crescendo or when a kick drum is hit, or indeed when anything happens fast and / or loud, a mains conditioner can act as a bottleneck and compromise the systems ability to deliver power when it's needed, resulting in a rather strangled, unrealistic sound.
Trevor79 (Technical member)
Besides filtering out RFI and stray Voltage on the neutral path, for dynamics not to be strangled Mains conditioning needs to address headroom in its supply to power amplification.
Current demands (draw) made off the both the music and its transients (up to 10x higher than the stable draw (volume)).
A normal house Mains supply on a 20A ring circuit struggles to deliver this, that's why reservoir capacitance is built into internal power supplies. The size of them and the recharge rate determines if they run out or not. For amplification to work effortless they need to be able to cope and deliver transient demands.
Now this is the interesting bit, apart from custom built, or highly modified power amps the capacitance in almost all equipment is lacking by at least a factor of 2 and often by 4!
So they are already marginal in following music at decent outputs. If the Mains conditioning slows down the supply it has an audible effect.
Whilst I don't have personal experience on the Isotek Minisub it doesn't appear to have any in built capacitance to it. The bottle neck I see is it plugged into a 20A ring main, by a 13A fused plug, which then feeds the unit with 2 x 10A rated outlets. (2 x 10A = 20A loading on the ring main wiring)
In reality you have a loading that is capped by the 13A plug fuse divided by 2 = 6.5A per power amp!
Are you disappointed with the music dynamics by any chance?