If the cable you are using is not thick enough for your amp power to the speakers, (Go for 2.5mm sq. OFC cable) then yes there may be a difference due to the lower resistance of having the 2 cables in parallel, (You would get the same effect if you used a thicker single wire cable) otherwise no. (Any difference (Assuming you are not performing a level matched double blind test) will most likely be just the placebo effect)
If you already have some cable, than as mentioned above just try them out and stick with the cables that sound best to you. (Whether it is the placebo effect or not is irrelevant if it makes you happy)
Bill