I would go with option two any day ( LS50 wireless + sub )
The R500's will need a lot of room around them to perform well. That said the LS50's also need decent room, but will be less than the R500.
The above said, the biggest problem with speakers in a small room is bass. But with a sub woofer doing the duties below 80hz, you have the option of experimenting with the location of the sub for best bass performance without bass boom.
You could add a wireless subwoofer kit, and it will give you more flexibility with sub woofer placement, as long as a power point is at hand.
And for me at least bass is important. I would always use a subwoofer for bass for music any day, as compared to just 2 speakers.