Definitely.
There's way too many posts on forums with regards to all replacement model lines are just tweaks, that they're basically the same, and that it is just attention seeking by manufacturers to get stuff re-reviewed. Looks can be deceiving to those who haven't done any research. Like the current Bowers & Wilkins 800 Series, PMC's TwentyFive Series is a completely different range, with very few components carried over to the new models. If I recall correctly, the screws for the HF unit are the same - other than that everything is a different component, different material, different design, even different cabinet dimensions.
In our 16th century demo rooms (no solid walls, probably akin to a Barrett's type home), we found the Twenty Series quite lean sounding, and would usually lose out to most other ranges in the bass presence department because of it. The TwentyFives address that, and bring that missing bass back. They'll play louder too (not that the older ones weren't loud enough), as the material used can take more punishment. Whilst the bass is the most immediately different aspect between the two ranges, many other aspects have been improved too. They're better built with thicker cabinets, so they're now more transparent. They're far more detailed too, despite the improved bass performance. Midrange also benefits from the better mid/bass driver too.
They're just as easy a load as the older Twenty Series too, so if your amplifier is doing a decent job with the Twenty.22, it'll be fine with the TwentyFive.22 too. Get a demo if you can just to confirm they're what you're looking for, but I doubt you'll be disappointed with them. They're certainly on my radar come my next upgrade.