I know the room is where it all starts, and where the biggest gains are to be made. Unfortunately, other people live there... so i fiddle with speaker positioning and some cushions, blankets, etc. I wish i had a proper listening room.
One of the reasons i chose KEF at the time was the Uni-Q tweeter that isn't fussy. It lets me keep the towers facing (almost) straight so the staging remains wide and doesn't lose center focus. It seems to work well, but i change the distance and angle from time to time. I should probably look into ways to measure/correct/optimize.