I have tried both speakers on my Cambridge 740A.
The X12's are by far the easiest to drive, but the sound from the Focus 110's leaves the X12's in the dust. The bass goes really deep on those small speakers, and the dynamics are superb. The only downside is that they require at least 200 hours of burn in, but the wait is rewarding. They are both very detailed and very dynamic speakers, but if you go for the Focus 110's (which I own myself and would HIGHLY recommend) you need to look for an amplifier with high currents. My 740A barely have enough juice.