Synergy is basically matching components that compliment each other.
Example : Amplifier matching
I have had two pais of 80dB speaker (ATC SCM10 and Keesonic Kolt). I have tried a variety of amplifier with them-
Bantam Gold (15wpc), T-Amp (8wpc), Decware Zen SET (2wpc), Denon PMA-2000AE (80wpc), Sony TA-F670ES (90wpc), Rega Brio3 (38wpc), Arcam AVR200 (85wpc) and Sony TA-F770ES (90wpc).
And the best with the Kolts was the Decware, T-Amp and 770ES. Now thats quite a large range of power outputs that seem to work really well, when in theory it should not. The Decware worked really well just from a 'hifi' view as it had the best soundstage, amazing mid-range and a very fast, punchy mid bass. We measured it and it was producing about 1% 2nd Harmonic distortion at ~0.6w output, and you know what, it sounded great!
The 770ES was the opposite where the soundstage was nothing special, but it has oodles of power that only really was noticable bass transistents but just sounded 'right' overall.
As an example, the PMA-2000AE had the same oodles of power but really sucked all the life out of it so I would say there is more than distortion/lack of clipping to amp and speaker matching.
In real world use, I could not get either the T-Amp or Decware to clip with 80dB speakers, so IMO, distortion and clipping is only an issue if you are playing far too loud anyway.