Paulwbm:Wife's new Toshiba laptop running Itunes (Apple lossless files), connected via USB port on Cambridge DACMagic (which currently serves as the DAC for the CD6000). This only allows CD quality (16bit/44KHz) over its USB port. Result, probably as good as the CD, sound might be a little brighter, less warm, but certainly very clear and detailed.
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I appreciate that this is all a bit unscientific and that I have a number of limiting factors
Unscientific indeed...
To really compare, you must be able to switch between the music samples immediately, without leaving your listening position. Any delay between samples will mean you're comparing memories; not sound. Any movements will mean changes to the acoustic environment (you can easily test this with a microphone and proper software: Moving the mic as little as half an inch might result in a change in frequency response, big enough to be audible).
Unless the PC messes up things, the only possible limiting factors are the DAC used, the quality of the music files.
As for the samples, I trust the lossless files are ripped from the same CD you're using -- otherwise, it might actually be a different mix. Be sure all 'sound improvement' is turned off in iTunes or other software: EQs and such things will certainly change the sound. Using the default settings might mean there's some 'improvement' going on; be sure you turn it off.
The USB port on the DAC uses a different receiver chip than the S/PDIF inputs. To compare sound quality, all samples should be played through the same kind of input.
Myself I use a remote controlled Inday S/PDIF switch (allowing both coaxial and optical connections), that allows me to switch immediately between different digital sources, using the same DAC input.
Still, knowing what source you're listening to, allows for prejudices that might influence your impression. For a fair test you should not know which sample is which. For a reasonably scientific approach, you should not even know when there's actually a change of samples, and when it's the same sample being repeated.