There's been a proliferation of golden eared nonsense over the years, but thankfully that seems to have balanced out over recent years.
I still find the notion of £10,000 for a metre long cable is abject nonsense, but beyond that, my only tweakery is moving my speakers every now and then when new gear comes in. When the NAD amp was introduced the other week, I needed to move the AVI actives, and moreso when the Mordaunt Short MS10i pair arrived. And that's about it. I don't usually mess around with anything else.
The major downside of all of the nonsense is it often drowns out the good stuff that's talked about in the hobby.