Yes, you can use FIR in Minidsp some products that includes 2x4 HD. However you need to design filters in another software. Hence my question about rePhase. rePhase is free to use and one of many programmes you could use to do it. There are some interesting paid solutions that help as are not fully manual and offer a little more however cost can be high.
As to differences between Roon DSP and Minidsp. From memory 2x4 HD can used 9,600 taps in total (length of filter). That's 4,800 per channel. OpenDRC DA-8 had more but not by much (around 12,000 total if I remember it right). If you're considering correction in bass using FIR such filters will not do much as they're just too short. So most likely you will correct bass with parametric EQ and mids, treble and phase with FIR. Also you're forced to use specific sampling rate with 2x4 HD it's 96kHz. That means anything sent to Minidsp will be resampled to 96kHz. That's not ideal.
In rePhase which I'm using I can design filters that are 131,000 taps long. That's 131,000 taps per channel. Also I can create them in various sampling rates. You then put all the filters in a zip archive and Roon selects filter with appropriate sampling rate automatically depending on track being played.
With Minidsp I couldn't design FIR filters that were good enough as the units just lacked processing power. Roon has power to spare. This is not to say I discourage use of Minidsp as I rate their products. However it's worth knowing what the limitations are.