Looks quite flexible. Maybe not as flexible as a pronto (e.g. I did not see a 'delay' function. or have I just overlooked it? button size only stadard, no computer-based set-up etc) but probably still flexible enough for any system.
I was hoping so much that new ipods and the ipad would have a built-in IR sender/receiver - that woudl make it ideal for using as advanced remote, but no luck so far. These add-ons are OK but a bit awkward (dongles) or need extra boxes+power (wifi boxes), so a built-in IR one would have been so much neater and way more fitting with the whole apple's slick styling thing.
Anyhow, looks very good.