As it happens, I have the Mezzo 2s and the Kef 2005.2s in my house. I can assure you that the 2005.2s will sound pretty dire compared to the Mezzos for music - on my amp switching between the two for music is like chalk and cheese (and that's with an old yamaha surround amp and a PS3 playing the music)!
The only really small speakers that I have found sound any good are the Anthony Gallo A'Divas, preferably with a sub (but are ok without, at a push).
Try convicing the wife to let you place the Mezzos either side of the desk on stands, perhaps?