Yes, I have this amp, running with a 540C and, until recently, biwired to Eltax monitor IIIs (now upgraded to Epos), so was very similar to your set up. I'm afraid, however, that I can't comment on the difference biwiring makes on this amp, as I didn't try single wiring it first. I can tell you that it sounds very nice though. Whether or not it will sound significantly, or even noticeably better than your current single-wired configuration, is something you'll only find out by trying it.
I did, however, try both single and bi with the 540c and the Eltaxs when I was running a Cambridge A1 mk3, and got slightly better clarity and brightness in the top end.
Your results may vary, obviously.