For low current application the number of strings would be meaningless. However, for high current applications this is fairly important due to Electro-Motive Force produced by current.
When AC travels through two conductors next to eachother they repell because of this EM Force. Even in a single wire, there are structural string and you can look at it like a multistring composition, just very dense. The EMF pushes eventually more current on the outside of the wire than the inside. This for small current is negligable but for high current, like welding, its important. Therefore, a multistring cable would be more efficient and more practical (bendy) than solid core or few thick strings.
The more difficult speaker drivers are to move, bigger their resistance (impedance) is. Speakers that go to or under 1 ohm are basically cables connected to a pile of rocks, expecting sound to come of it. 0 hms resistance is when you weld.
Now, unless your amp delivers High Instanteneous Current of 200A or more in transient peaks and the speakers need it and can take it, you are good with normal stock 75 string speaker cable. But if you have Krell amplification and Apogee speakers, you will want that orange welding cable that goes up to 600A.