This could a huge conversation right here in your own post, but it's one that has been debated, a lot!
I think you may want to elaborate on your question and details a little to give us all a picture of what you would like to do, as it too difficult to answer in a few sentences. Image how many speakers there are in the world and then cables. Many suit one another, many don't and it's a matter of personal choice in most cases of whether you believe it sounds better from a cable that cost you £10 to something that may have cost you £100.
Like the Chicken and the egg... what came first, the cable or the speaker?