Thanks everyone for your input!!!
Here is a list of my prime suspects:
1) Room
I have my setup in the basement in the corner, but my basement is quite large and open. The left side is a wall with a fireplace, while the right side is very open with no walls. The speakers are facing in front of a large window.
2) Wireworld Stream 16/2 speaker cable
I'm using Wireworld Stream 16/2 speaker cable, which is a highly rated cable, but might not be suitable for system. The midrange is severely missing, perhaps I need a thicker 12 awg cable. For anyone who has heard Inna (House/dance music), her voice is supposed be really bright and my speakers are supposed to be bright, but her voice feels too laid back and not defined accurately. I need brighter cables...
3) 6N Copper Coxial Cable
This cable is made in Canada by an audiophile, who sells extremely high quality cables at low prices. I have not compared the cable to anything else, but usually coax cables do not make as much difference as regular ICs as the sound transmitted is digital. Hard to say right now...
4) JRiver 16 software
Using Asio driver and this is highly regarded software used by audiophiles, so it hard to say if it's a software issue.
5) 12 awg Silver/Copper Mains cord
This actually makes my system clearer and smoother, so it actually optimises my system, but takes away a bit of slam.
6) Klipsch speakers
Klispch are supposed be bright and dynamic with vocals, but I'm not feeling enough air and midrange clarity is severely lacking.
My possible speaker upgrades:
a) KEF R500
b) Tannoy DCT6 SE
c) Triangle Color Floorstanders
d) PSB Imagine T
Can anybody help me choose which is best speaker out of the four I have listed? Thanks.