I initially single-wired my RS6's with my Alpha 9 integrated amp and they sounded great
I then bi-wired them using both sets of speakers outputs on the amp and there was definitly a difference. The bass was fuller and better timed, the midrange again improved with timing and the treble had better clarity. Theyve stayed bi-wired ever since and are soon to be bi-amped.
I'd say go for bi-wire. If you dont have 2 sets of putputs on your amp just go 2 to 4.